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Report #2828511

Received Feb 26, 2025

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A note on interpretation. VAERS reports are unverified and may be incomplete or coincidental. A report does not establish that a vaccine caused an event, and counts should not be used to calculate incidence or infer causation. Full disclaimer

Overview

Sex
Male
Age
30 yrs
State
TX
Recovered
Not recovered
Vaccinated
Feb 4, 2021
Onset
Feb 7, 2021
Days to onset
3
Hospital days
—

Vaccines (1)

TypeNameManufacturerDoseLotRoute / Site
COVID19COVID19 (COVID19 (MODERNA))MODERNA2028L20AIM / UN

Symptoms (11)

Abdominal painBlood alkaline phosphatase increasedCOVID-19Computerised tomogram abdomen normalMalaiseNauseaPrimary biliary cholangitisScan with contrast normalSmooth muscle antibody positiveTransaminases increasedVomiting

Symptom narrative

The following events are before any COVID19 infection: first 48H after the vaccine administration, developed malaise, 72H after vaccine administration started with severe abdominal pain, nausea and vomiting, that prompted ED visit.

Current illness

Biliary colic, vit. D deficiency.

Other medications

None.

Allergies

None.

Lab data

In the ED mild elevation of transaminase was noticed, CT abdomen and pelvis with contrast was normal, sent home with recommendations. Over the course of months and in the past few years progressive increase in Alkaline phosphatase levels were noticed 121 (Feb. 2021); 155 (April 2021); 161 (Jan. 2024); 171 (June 2024); 169 (Nov. 2024); 167 (Jan. 2025): Isoenzymes measured showed elevation was secondary to liver 2 alkaline phosphatase; repeated alkaline phosphatase on February 2025 showed 146. Symptomatic COVID infection happened on early 2022 (likely spring). Covid Shots are as follows: Moderna #1 (Jan. 2021), Moderna #2 (Feb. 2021), Moderna #3 (Dec. 2021), Moderna #4 (Nov. 22), Pfizer #1 (Nov. 2024). Elevation of alkaline phosphatase prompted autoimmune liver work-up which so far appears to show evidence of autoimmune process going on, with anti smooth muscle antibodies positive, likeliest in the differential is Primary biliary cholangitis. This appears to correlate with case reports of cases of overlap between primary biliary cholangitis and autoimmune hepatitis shortly after COVID19 vaccination, but case reports describe more acutely ill patients. Alk Phos levels appears to correlate with the re-application of the vaccine. Work-up is still undergoing.