Report #2832336

Overview

Sex

Male

Age

Age unknown

State

MA

Recovered

Unknown

Vaccinated

—

Onset

—

Days to onset

—

Hospital days

—

Symptoms (2)

Symptom narrative

His response to pneumococcal polysaccharide vaccine was minimal; This literature marketed report has been received from the authors of a published literature article, and refers to a male patient of unknown age with recurrent sinus infections, pneumonia throughout childhood with chronic diarrhea, positive tissue transglutaminase IgA, and endoscopy with small bowel enteropathy leading to a diagnosis of celiac disease. Owing to recurrent infections, immunodeficiency evaluation at age 15 years revealed mildly low IgG level with normal IgA and elevated IgM levels. The patient had a pathogenic mutation in PIK3CD. On an unknown date, the patient was vaccinated with an unspecified pneumococcal vaccine (dose, route of administration, lot # and expiration date were not provided), for prophylaxis. His response to the suspect vaccine was minimal. The outcome of the event was not provided. He was started on immunoglobulin replacement leading to decreased infections. The authors of the article considered minimal response to the vaccine as related to pneumococcal vaccine. This is one of 3 reports derived from the same literature article (linked GSD #2266119 and 2266118).

Current illness

Celiac disease (endoscopy with small bowel enteropathy led to a diagnosis of celiac disease/ positive tissue transglutaminase IgA, chronic diarrhea); Gene mutation; Pneumonia (throughout childhood); Sinus infection (throughout childhood)