Report #2832347

Overview

Sex

Female

Age

Age unknown

State

MA

Recovered

Unknown

Vaccinated

—

Onset

—

Days to onset

—

Hospital days

—

Symptoms (1)

Symptom narrative

did not respond to pneumococcal polysacharide vaccination; This literature marketed report has been received from the authors of a published literature article, and refers to a female patient of unknown age. She had a history of recurrent strep throat in young childhood, but no other significant infections. At age 16 years, she was diagnosed with hypothyroidism with goiter and underwent total thyroidectomy with pathology noting significant lymphocytic infiltrate. She developed joint pains and fevers at age 32 years and was diagnosed with having seronegative rheumatoid arthritis. Trialed treatments included multiple immunemodulators including hydroxychloroquine, methotrexate, tumor necrosis factor inhibitors, andsteroids. She transitioned to abatacept with dramatic improvement in her joint pain and was tapered off steroids. During this time, she had moderate hypogammaglobulinemia in the setting of frequent upper respiratory infections. She had heterozygous CTLA-4 mutation. Her son was diagnosed with inflammatory bowel disease. On an unknown date, the patient was vaccinated with an unspecified pneumococcal vaccine (dose, route of administration, lot # and expiration date were not provided), for prophylaxis. She did not respond to the suspect vaccine. The outcome of the event was not provided. The authors of the article considered lack of response to the suspect therapy as related to pneumococcal vaccine. Lot # is being requested and will be submitted if received. This is one of 3 reports derived from the same literature article (linked GSD #2266119 and 2263700).

Current illness

Gene mutation; Goiter (diagnosed at age 16 years); Hypogammaglobulinemia; Hypothyroidism (diagnosed at age 16 years); Inflammatory bowel disease (son); Seronegative rheumatoid arthritis; Upper respiratory infection

Medical history

Medical History/Concurrent Conditions: Streptococcal sore throat (in young childhood); Thyroidectomy (with pathology noting significant lymphocytic infiltrate.)