Report #2832348

Overview

Sex

Female

Age

Age unknown

State

MA

Recovered

Unknown

Vaccinated

—

Onset

—

Days to onset

—

Hospital days

—

Symptoms (1)

Symptom narrative

poor response to pneumococcal vaccination.; This literature marketed report has been received from the authors of a published literature article, and refers to a female of unknown age with history of autoimmune thyroid disease presented with recurrent mucocutaneous candidiasis. She was diagnosed with having autoimmune thyroid disease at age 7 years and on thyroid replacement. She had 6 lifetime pneumonias that responded to antibiotics and was recently found to have bronchiectasis on computed tomography scan. Since age 5 years, she had recurrent mucocutaneous candidiasis treated with numerous courses of fluconazole. Her sister was diagnosed with having type 1 diabetes at age 12 years and had less severe mucocutaneous candidiasis. IgG, IgA, and IgM levels were normal. IgG2 level was low. She had STAT1 GOF mutation. On an unknown date, the patient was vaccinated with an unspecified pneumococcal vaccine (dose, route of administration, lot # and expiration date were not provided), for prophylaxis. She had a poor response to the suspect vaccine. The outcome of the event was not provided. The authors of the article considered poor response to the suspect therapy as related to pneumococcal vaccine. Lot # is being requested and will be submitted if received. This is one of 3 reports derived from the same literature article (linked GSD #2266118 and 2263700).

Current illness

Autoimmune thyroid disorder; Bronchiectasis; Gene mutation; Mucocutaneous candidiasis; Type 1 diabetes mellitus (sister)

Medical history

Medical History/Concurrent Conditions: Pneumonia (6 lifetimes pneumonias)