Received Jul 22, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| COVID19 | COVID19 (COVID19 (MODERNA)) | MODERNA | 3 | 064H21A | — |
I do believe my two Moderna booster vaccines are affecting the results of my thyroid TSH test. After the first booster, my TSH numbers increased more than double.; After my second booster, my TSH numbers fell to an extremely low number; my eyes have been very blurry; my hair is falling out. I'm losing so much of my hair" and "my eyes have been very blurry; Pulse rate low; just so tired/kind of tired; currently prescribed Synthroid 100 mcg daily but taking Synthroid 112 mcg once daily instead; my skin in that area is darker; The large red part is below the injection site. It was slightly swollen and was eight degrees hotter than the rest of my skin/the bright red part was slightly swollen and we have a temperature probe; This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin; The large red part is below the injection site. It was slightly swollen and was eight degrees hotter than the rest of my skin/the bright red part was slightly swollen and we have a temperature probe; This area was painful/physically it was just the normal kind of hurting of the arm; The large red part is below the injection site/~the second booster, I had a very bad reaction to it. Below the injection site, my arm turned bright red; This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin; This spontaneous case was reported by a consumer and describes the occurrence of BLOOD THYROID STIMULATING HORMONE INCREASED (I do believe my two Moderna booster vaccines are affecting the results of my thyroid TSH test. After the first booster, my TSH numbers increased more than double.), BLOOD THYROID STIMULATING HORMONE DECREASED (After my second booster, my TSH numbers fell to an extremely low number), VISION BLURRED (my eyes have been very blurry), ALOPECIA (my hair is falling out. I'm losing so much of my hair" and "my eyes have been very blurry) and DILATED PORES (This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin) in a 75-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) (batch nos. 05FMZ1/IP and 064H21A) for COVID-19 prophylaxis. The occurrence of additional non-serious events is detailed below. Co-suspect product included non-company product Levothyroxine sodium (Synthroid) for Thyroid disorder. The patient's past medical history included Radioactive iodine therapy in 1980. Previously administered products included for COVID-19 prophylaxis: Moderna (First dose, Lot - 008B21A) on 23-Mar-2021, Moderna (Second dose and Lot - 047B21A) on 21-Apr-2021. Past adverse reactions to the above products included No adverse effect with Moderna and Moderna. On 18-Nov-2021, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) 1 dosage form. On 24-May-2022, received fourth dose of mRNA-1273 (Moderna COVID-19 Vaccine) (unknown route) dosage was changed to 1 dosage form. In January 2025, Levothyroxine sodium (Synthroid) (unknown route) dosage was changed to 150 microgram. On an unknown date, the patient started Levothyroxine sodium (Synthroid) (unknown route) 137 microgram. On an unknown date, Levothyroxine sodium (Synthroid) (unknown route) dosage was changed to 125 microgram and Levothyroxine sodium (Synthroid) (unknown route) dosage was changed to 112 microgram once a day. On 28-May-2022, the patient experienced DILATED PORES (This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin), VACCINATION SITE WARMTH (The large red part is below the injection site. It was slightly swollen and was eight degrees hotter than the rest of my skin/the bright red part was slightly swollen and we have a temperature probe), VACCINATION SITE DRYNESS (This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin), VACCINATION SITE SWELLING (The large red part is below the injection site. It was slightly swollen and was eight degrees hotter than the rest of my skin/the bright red part was slightly swollen and we have a temperature probe), VACCINATION SITE PAIN (This area was painful/physically it was just the normal kind of hurting of the arm) and VACCINATION SITE ERYTHEMA (The large red part is below the injection site/~the second booster, I had a very bad reaction to it. Below the injection site, my arm turned bright red). In 2025, the patient experienced VACCINATION SITE DISCOLOURATION (my skin in that area is darker). On an unknown date, the patient experienced BLOOD THYROID STIMULATING HORMONE INCREASED (I do believe my two Moderna booster vaccines are affecting the results of my thyroid TSH test. After the first booster, my TSH numbers increased more than double.), BLOOD THYROID STIMULATING HORMONE DECREASED (After my second booster, my TSH numbers fell to an extremely low number), VISION BLURRED (my eyes have been very blurry), ALOPECIA (my hair is falling out. I'm losing so much of my hair" and "my eyes have been very blurry), HEART RATE DECREASED (Pulse rate low), FATIGUE (just so tired/kind of tired) and INTENTIONAL PRODUCT USE ISSUE (currently prescribed Synthroid 100 mcg daily but taking Synthroid 112 mcg once daily instead). At the time of the report, BLOOD THYROID STIMULATING HORMONE INCREASED (I do believe my two Moderna booster vaccines are affecting the results of my thyroid TSH test. After the first booster, my TSH numbers increased more than double.), BLOOD THYROID STIMULATING HORMONE DECREASED (After my second booster, my TSH numbers fell to an extremely low number), DILATED PORES (This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin), VACCINATION SITE DISCOLOURATION (my skin in that area is darker), VACCINATION SITE PAIN (This area was painful/physically it was just the normal kind of hurting of the arm), VACCINATION SITE ERYTHEMA (The large red part is below the injection site/~the second booster, I had a very bad reaction to it. Below the injection site, my arm turned bright red), FATIGUE (just so tired/kind of tired) and INTENTIONAL PRODUCT USE ISSUE (currently prescribed Synthroid 100 mcg daily but taking Synthroid 112 mcg once daily instead) outcome was unknown, VISION BLURRED (my eyes have been very blurry), ALOPECIA (my hair is falling out. I'm losing so much of my hair" and "my eyes have been very blurry), HEART RATE DECREASED (Pulse rate low) and VACCINATION SITE DRYNESS (This area was painful and my skin became dry plus my pores were enlarged/It was a very weird reaction. the area that was very red, it just dried out my skin and it enlarged the pores of my skin) had not resolved and VACCINATION SITE WARMTH (The large red part is below the injection site. It was slightly swollen and was eight degrees hotter than the rest of my skin/the bright red part was slightly swollen and we have a temperature probe) and VACCINATION SITE SWELLING (The large red part is below the injection site. It was slightly swollen and was eight degrees hotter than the rest of my skin/the bright red part was slightly swollen and we have a temperature probe) was resolving. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Heart rate: now is my pulse rate is getting to be much lower than it should be low pulse rate went all the way down below normal.. On an unknown date, Thyroid function test: abnormal and TSH number "shot way up went more than double the number of normal. They went way up into the high area.. For mRNA-1273 (Moderna COVID-19 Vaccine) (Unknown), the reporter did not provide any causality assessments. Concomitant medication was not reported. It was reported that everything went well with the first two shots. It was reported that after second booster, patient had a very bad reaction. Below the injection site, the arm turned bright red and the bright red part was slightly swollen and that red part was 8 degrees hotter than the rest of the skin it lasted, and it started fading a little bit after a week and then it gradually started fading. Patient had problems with her thyroid tests. Patient had radioactive iodine from the thyroid in 1980 and was perfectly fine until had the first booster. The spot was visible the area on my arm where it affected my arm. After first COVID booster shot, physically it was just the normal kind of hurting of the arm, kind of tired, so not any big deal but patient's TSH number shot way up it went more than double the number of normal and with the second one, TSH number went all the way down below normal. Patient was prescribed Synthroid 100 mcg daily but taking Synthroid 112 mcg once daily instead. It was reported that the problem was that endocrinologist kept lowering the thyroid amount and patient was having so many symptoms, not getting enough thyroid medication and endocrinologist lowered it again on 09-Jul-2025 and was having terrible symptoms for not getting enough of the thyroid. It was unknown if the patient experienced any additional symptoms/events. Most recent FOLLOW-UP information incorporated above includes: On 10-Jul-2025: Live follow-up received. Medical history and new events added. Suspect details were updated.
Medical History/Concurrent Conditions: Radioactive iodine therapy
SYNTHROID
Test Name: Pulse rate; Result Unstructured Data: now is my pulse rate is getting to be much lower than it should be low pulse rate went all the way down below normal.; Test Name: Thyroid function tests; Result Unstructured Data: abnormal; Test Name: Thyroid function tests; Result Unstructured Data: TSH number "shot way up went more than double the number of normal. They went way up into the high area.