Received Aug 11, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| PPV | PNEUMO (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
| PPV | PNEUMO (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
| PPV | PNEUMO (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
No immunologic response to pneumococcal vaccination; This literature marketed report has been received from the authors of a published literature article, and refers to a 51-year-old male patient. The patient's concomitant therapies were not reported. On an unknown date, about 20 years prior to presentation, the patient a mediastinal mass found; at that time, biopsies were non-diagnostic. The patient was empirically treated for tuberculosis with reported improvement in the mass size. On an unknown date in early 2024, the patient developed influenza pneumonia, and computerized tomography (CT) scan showed a 10 cm mediastinal mass with bronchiectasis and ground glass opacities concerning for infection. Positron emission tomogram (PET)/CT scan showed moderate uptake in the mass, but no evidence of extra-thoracic FDG-avidity. On an unknown date in 2024, the patient underwent resection of the mass with wedge resection of the left upper lobe with clear margins and lymph nodes negative for malignancy. Pathology test showed thymoma, predominantly type A, 11.8 x 8.1 x 5.8 cm with pulmonary parenchymal invasion. On an unknown date, two months after tumor resection, the patient was admitted to hospital with pneumonia and found to have hypogammaglobulinemia with IgA less than 25 mg/dL, IgM less than 25 mg/dL and IgG 133 mg/dL. Screening serologies were negative for connective tissue disease. Pulmonary function testing showed severe restrictive lung physiology, forced vital capacity (FVC) was 1.11 (unit not provided) (z-score -5.94), forced expiratory volume in 1 second (FEV1) was 1.11 (unit not provided) (z-score -4.60), and FEV1/FVC was 1.00 (unit not provided). Serologic evaluation, lung function, and imaging findings supported a clinical diagnosis of granulomatous lymphocytic interstitial lung disease (GL-ILD) related to Good Syndrome. On an unknown date, the patient was vaccinated with pneumococcal vaccine (manufacturer unknown), administered for prophylaxis (dose, route of administration, anatomical location, lot# and expiry date were not reported). On an unknown date, the patient had no immunologic response to pneumococcal vaccination, confirming a diagnosis of primary hypogammaglobulinemia The outcome of the event was not reported. The authors considered the event of no immunologic response to pneumococcal vaccination to be related to suspect vaccine. Lot# is being requested and will be submitted if received.
Bronchiectasis; Good syndrome; Granulomatous lymphocytic interstitial lung disease; Hospitalization; Pneumonia
Medical History/Concurrent Conditions: Partial lung resection; Pneumonia influenzal; Tumor resection
Test Name: biopsies; Result Unstructured Data: non-diagnostic; Test Name: Pulmonary function testing; Result Unstructured Data: severe restrictive lung physiology; Test Date: 2024; Test Name: CT imaging; Result Unstructured Data: a 10 cm mediastinal mass with bronchiectasis and ground glass opacities concerning for infection; Test Date: 2024; Test Name: PET/CT; Result Unstructured Data: moderate uptake in the mass, but no evidence of extra-thoracic FDG-avidity; Test Date: 2024; Test Name: Pathology test; Result Unstructured Data: thymoma, predominantly type A, 11.8 x 8.1 x 5.8 cm with pulmonary parenchymal invasion; Test Name: IgA; Result Unstructured Data: less than 25 mg/dL (hypogammaglobulinemia); Test Name: IgM; Result Unstructured Data: less than 25 mg/dL (hypogammaglobulinemia); Test Name: IgG; Result Unstructured Data: 133 mg/dL (hypogammaglobulinemia); Test Name: Screening serologies; Result Unstructured Data: negative for connective tissue disease; Test Name: FVC; Result Unstructured Data: 1.11 (unit not provided) (z-score -5.94); Test Name: FEV1; Result Unstructured Data: 1.11 (unit not provided) (z-score -4.60); Test Name: FEV1/FVC; Result Unstructured Data: 1.00 (unit not provided)