Received Sep 23, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| COVID19 | COVID19 (COVID19 (MODERNA)) | MODERNA | UNK | — | — |
Moderna Vaccine activated her MS/low energy; This spontaneous case was reported by a consumer and describes the occurrence of MULTIPLE SCLEROSIS RELAPSE (Moderna Vaccine activated her MS/low energy) in an elderly female patient who received SPIKEVAX NOS (SPIKEVAX NOS) for COVID-19 prophylaxis. Previously administered products included for Product used for unknown indication: Pfizer covid vaccine (Dose 1, Lot: EM9810, Site: Injection in the arm) on 03-Feb-2021, Pfizer vaccine (Dose 1, Lot: EM9810, Site: Injection in the arm) on 03-Feb-2021, Pfizer vaccine (Dose 2, Lot: EN6198, Site: Injection in the arm) on 26-Feb-2021, Pfizer covid vaccine (Dose 2, Lot: EN6198, Site: Injection in the arm) on 26-Feb-2021, Pfizer covid vaccine (Dose 3, Lot: FH8027, Expiry: 28Feb2022, Site: Injection in the Right arm) on 22-Oct-2021, Pfizer vaccine (Dose 3, Lot: FH8027, Expiry: 28Feb2022, Site: Injection in the Right arm) on 22-Oct-2021, Pfizer covid vaccine (Dose 4, Lot: FN2908, Site: Injection in the arm) on 10-May-2022, Pfizer vaccine (Dose 4, Lot: FN2908, Site: Injection in the arm) on 10-May-2022, Pfizer covid vaccine (Dose 5, Lot: C1 or CJ3270, Site: Injection in the arm) on 19-May-2023, Pfizer vaccine (Dose 5, Lot: C1 or CJ3270, Site: Injection in the arm) on 19-May-2023, Pfizer vaccine (Dose 6, Lot: 6JZ524 or 6J2524, Date: 13Sep2022) on 13-Sep-2023, Pfizer covid vaccine (Dose 6, Lot: 6JZ524 or 6J2524 and Date: 13Sep2022) on 13-Sep-2023. Past adverse reactions to the above products included Pain in arm with Pfizer covid vaccine, Pfizer covid vaccine, Pfizer covid vaccine, Pfizer covid vaccine, Pfizer covid vaccine and Pfizer covid vaccine; and Strength loss of with Pfizer vaccine, Pfizer vaccine, Pfizer vaccine, Pfizer vaccine, Pfizer vaccine and Pfizer vaccine. Concurrent medical conditions included Multiple sclerosis (she had MS for 30 years.). On an unknown date, the patient received seventh dose of SPIKEVAX NOS (SPIKEVAX NOS) (unknown route) 1 dosage form. On an unknown date, the patient experienced MULTIPLE SCLEROSIS RELAPSE (Moderna Vaccine activated her MS/low energy) (seriousness criterion medically significant). At the time of the report, MULTIPLE SCLEROSIS RELAPSE (Moderna Vaccine activated her MS/low energy) had not resolved. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On an unknown date, Magnetic resonance imaging: Stable and did not show any active lesions or anything. Concomitant medication was not provided. It was reported that the patient was 68-69 years old at onset and reported her weight as too much and stated that she was completely mobile. It was reported that the patient had MS for 30 years and had received original covid vaccine in 2020. She had received 6 booster doses from Pfizer and reported that she had not experienced any problems and was doing well. She also reported that she had experienced a flu shot type response with the Pfizer covid vaccines. She had received her 7th booster dose from Moderna, and the Moderna vaccine had activated her MS leading to a robust response for which she had to go on corticosteroids due to MS complications. The complications included low energy and difficulty getting out of bed. Her neurologist had advised her against getting another covid vaccine which had been 2 years ago. She was ambulant but did not want to risk activating her MS and she was seeking advice on whether or not to get the new vaccine. She was worried about having a robust response to the COVID vaccine and did not want to aggravate her MS. It was also reported that she was on an immunosuppressant at the time she had the Moderna vaccine but was modulated. She clarified that she had a sore arm and down with energy a little bit for a day or so after receiving the Pfizer Covid-19 Vaccines which she was described as not a big deal and did not consider it as a negative outcome. She had stated that she did not want a recurrence of severe reaction she experienced with moderna vaccine, where she had struggled to get out of bed for a couple of weeks. The response to the Pfizer vaccine was described as level 1-2 compared to level 9-10 she had with Moderna. She noted that the difference was significant. It was way less than the shingles vaccines. It was not even on her radar. The patient also stated that the Moderna Covid-19 Vaccine had kicked her butt. The patient was not sure of lot number for 5th and 6th dose of Pfizer vaccin; Reporter's Comments: The previous vaccination with Pfizer vaccines and medical history of multiple sclerosis were assessed as confounding factors for reporting event of multiple sclerosis relapse. The benefit-risk relationship of product is not affected by this report.
Multiple sclerosis (she had MS for 30 years.)
Test Name: MRI; Result Unstructured Data: Stable and did not show any active lesions or anything