Received Sep 26, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| COVID19 | COVID19 (COVID19 (MODERNA)) | MODERNA | 3 | — | IM |
went into menopause; This spontaneous case was reported by a consumer and describes the occurrence of MENOPAUSE (went into menopause) in a 49-year-old female patient who received mRNA-1273 (Moderna COVID-19 Vaccine) for COVID-19 prophylaxis. Previously administered products included for Product used for unknown indication: TDap on 03-Jul-2008; for COVID-19 prophylaxis: Moderna COVID-19 vaccine (Dose 1) on 05-Mar-2021 and Moderna COVID-19 vaccine (Dose 2) on 09-Apr-2021; for Drug use for unknown indication: Wellbutrin xl (150 mg XL take 1 tablet every morning with 300 milligram) on 08-Jul-2021, Wellbutrin xl (300 mg XL take 1 tablet by mouth every day) on 08-Jul-2021, Adderall (10 mg Tablet) on 23-Jul-2021, Klonopin (0.5 mg Tablet) on 23-Jul-2021, Flovent hfa (44 mcg/ACT inhale 2 puffs as directed 2 times per day) on 28-Jul-2021, Flonase (50 mcg/ACT 1 spray by per nostril route 1 time per day spray in each nostril) on 11-Jan-2022 and Senna s (Senna 8.6 mg-docusate sodium 50 mg per tablet) on 03-Feb-2022; for Wheezing: Albuterol Hfa (inhale 2 puffs as directed every 4 hrs as needed) on 03-Aug-2021; for Allergy: Zyrtec (take 1 tablet by mouth once per day 10 mg) on 11-Jan-2022. Past adverse reactions to the above products included No adverse effect with Adderall, Albuterol Hfa, Flonase, Flovent hfa, Klonopin, Moderna COVID-19 vaccine, Moderna COVID-19 vaccine, Senna s, TDap, Wellbutrin xl, Wellbutrin xl and Zyrtec. Concurrent medical conditions included Asthma, Allergy to molds (cough, wheezing High criticality), Cervical facet arthrosis since 12-Sep-2016, Lumbar disc degeneration since 31-Oct-2016, Myofascial pain syndrome since 09-Jan-2017, Iron deficiency since 26-Jan-2018, Post-traumatic stress disorder (PTSD) since 26-Jan-2018, HLA-B*27 positive since 26-Jan-2018, Shoulder pain (Left Shoulder pain unspecified chronicity) on 10-Aug-2018, Ex-smoker (Former Cigarette smoker Quite:) 01-Jan-2001), Allergy (cough, wheezing High critically), Perfume allergy (cough, Headache, Nausea only, wheezing High criticality), Opioid type dependence, Ex-alcohol user (Not Currently 1 (1 unit=0.6 oz pure alcohol)) and Wheezing. Concomitant products included Buprenorphine hydrochloride (Subutex) from 29-Sep-2022 to an unknown date for Opioid type dependence, Salbutamol sulfate (Albuterol) from 10-Jan-2023 to an unknown date for Wheezing, Naproxen (Naprosyn) from 30-Sep-2022 to an unknown date and Vortioxetine hydrobromide (Trintellix) from 29-Sep-2022 to an unknown date for an unknown indication. On 31-Mar-2022, the patient received third dose of mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular use) 1 dosage form. On 31-Mar-2022, after starting mRNA-1273 (Moderna COVID-19 Vaccine), the patient experienced MENOPAUSE (went into menopause). At the time of the report, MENOPAUSE (went into menopause) had resolved. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): On 26-Jan-2018, HLA-B*27 assay: Positive. On 05-Oct-2022, Blood follicle stimulating hormone: 6.3 micro international unit per millilitre. On 05-Oct-2022, Blood pressure measurement: 115/71. On 05-Oct-2022, Blood thyroid stimulating hormone (0.34-5.60 micro international unit per millilitre): 1.95 micro international unit per millilitre TSH normal. FT4 not done. On 05-Oct-2022, Body height: 170.2 centimetre (5'7"). On 05-Oct-2022, Body mass index: 18.32. On 05-Oct-2022, Body temperature: 36.7 degree Celsius. On 05-Oct-2022, Haematocrit (34.1-44.2 %): 39.2 %. On 05-Oct-2022, Haemoglobin (11.6-15.1 g/dL): 12.0 g/dL. On 05-Oct-2022, Heart rate: 81. On 05-Oct-2022, Mean cell haemoglobin (27-33 picogram): 27.0 picogram. On 05-Oct-2022, Mean cell haemoglobin concentration (30-35 g/dL): 30.6 g/dL. On 05-Oct-2022, Mean cell volume (80-100 fL): 88.3 fL. On 05-Oct-2022, Neutrophil count (40-70 %): 40.1 %. On 05-Oct-2022, Oestradiol: 377 picogram per millilitre. On 05-Oct-2022, Oxygen saturation: 97 %. On 05-Oct-2022, Platelet count (150-450 10^9/L): 219 10^9/L. On 05-Oct-2022, Progesterone: 0.20 ng/mL. On 05-Oct-2022, Red blood cell count (3.9-5.2 10^12/L): 4.44 10^12/L. On 05-Oct-2022, Red cell distribution width (11-15 %): 13.9 %. On 05-Oct-2022, Respiratory rate: 14. On 05-Oct-2022, Weight: 53.1 kg (117 lb). On 05-Oct-2022, White blood cell count (3.8-11.2 10^9/L): 5.3 10^9/L. For mRNA-1273 (Moderna COVID-19 Vaccine) (Intramuscular use), the reporter did not provide any causality assessments. Concomitant medication included Albuterol Inh (Proventil/Ventolin). Patient never had smokeless tobacco. It was reported that this was patient third Moderna vaccine, a booster shot. Immediately after she took the shot, she went into menopause, that day, with no prior symptoms, five years earlier than usual for her family. This happened in 2022. Patient had the vaccine record somewhere. Patient received the vaccine at clinic in a mall. Patient went to a naturopath, and they were able to jump start her out of menopause with herbs for a few months, but then menopause came on full force again with no prior symptoms. She had since reported these events to her gynecologist and had started Hormone Replacement Therapy. The PHQ-2 total score was 2. It is unknown if there were additional lab data/results available. It was unknown if the patient experienced any additional symptoms/events. The patient did not have any additional medical history, concomitant disease or risk factor.
Allergy (cough, wheezing High critically); Allergy to molds (cough, wheezing High criticality); Asthma; Cervical facet arthrosis; Ex-alcohol user (Not Currently 1 (1 unit=0.6 oz pure alcohol)); Ex-smoker (Former Cigarette smoker Quite:) 01-Jan-2001); HLA-B*27 positive; Iron deficiency; Lumbar disc degeneration; Myofascial pain syndrome; Opioid type dependence; Perfume allergy (cough, Headache, Nausea only, wheezing High criticality); Post-traumatic stress disorder (PTSD); Wheezing
Medical History/Concurrent Conditions: Shoulder pain (Left Shoulder pain unspecified chronicity)
Naprosyn; Subutex; Trintellix; Albuterol
Test Date: 20221005; Test Name: FSH; Test Date: 20221005; Test Name: Blood pressure; Result Unstructured Data: 115/71; Test Date: 20221005; Test Name: TSH with reflex FT4; Result Unstructured Data: Test Result:1.95 u[iU]/mL;TSH normal. FT4 not done; Test Date: 20221005; Test Name: Height; Test Result: 170.2 cm; Test Date: 20221005; Test Name: Body mass index; Result Unstructured Data: 18.32; Test Date: 20221005; Test Name: temperature; Test Date: 20221005; Test Name: Hematocrit; Test Result: 39.2 %; Test Date: 20221005; Test Name: Hemoglobin; Test Date: 20221005; Test Name: Pulse; Result Unstructured Data: 81; Test Date: 20180126; Test Name: HLA-B*27; Test Result: Positive ; Test Date: 20221005; Test Name: MCH; Test Result: 27.0 pg; Test Date: 20221005; Test Name: MCHC; Test Date: 20221005; Test Name: MCV; Test Date: 20221005; Test Name: Neutrophils; Test Result: 40.1 %; Test Date: 20221005; Test Name: Estradiol; Test Date: 20221005; Test Name: Oxygen saturation; Test Result: 97 %; Test Date: 20221005; Test Name: platelet count; Test Date: 20221005; Test Name: Progesterone; Test Date: 20221005; Test Name: RBC; Test Date: 20221005; Test Name: RDW; Test Result: 13.9 %; Test Date: 20221005; Test Name: Respiratory rate; Result Unstructured Data: 14; Test Date: 20221005; Test Name: Weight; Test Result: 53.1 kg; Test Date: 20221005; Test Name: WBC