Received Oct 6, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| COVID19 | COVID19 (COVID19 (MODERNA)) | MODERNA | UNK | — | — |
myasthenia gravis; This spontaneous case was reported by a consumer and describes the occurrence of MYASTHENIA GRAVIS (myasthenia gravis) in a 64-year-old male patient who received mRNA-1273.712 (SPIKEVAX 2024-2025 PFS) for COVID-19 prophylaxis. The patient's past medical history included Prostate surgery in September 2024. Previously administered products included for Product used for unknown indication: shingrix in 2016, Pfizer (Dose 1) in 2021, Pfizer (Dose 2) in 2021 and flu shots (flu shots). Past adverse reactions to the above products included No adverse effect with Pfizer, Pfizer, flu shots and shingrix. Family history included Heart disorder. Concurrent medical conditions included Hypothyroidism. In March 2025, the patient received dose of mRNA-1273.712 (SPIKEVAX 2024-2025 PFS) (unknown route) 1 dosage form. In June 2025, the patient experienced MYASTHENIA GRAVIS (myasthenia gravis) (seriousness criterion medically significant). The patient was treated with Cefalexin in 2025 at an unspecified dose and frequency and Erythromycin in 2025 at an unspecified dose and frequency. At the time of the report, MYASTHENIA GRAVIS (myasthenia gravis) outcome was unknown. DIAGNOSTIC RESULTS (normal ranges are provided in parenthesis if available): In 2025, Blood test: The blood tests confirmed patient probably had it by some number that's supposed to be less than 0.02 when patient's result was like 3.7. No concomitant medications were provided. It was reported that after the surgery in March 2025, it was reported that he experienced an eye droop within the following 6 months and one day at breakfast his eye was half closed. The patient also experienced double vision. At that time the eye doctor treated it for 3 weeks with drops and Cefalexin and then erythromycin ointment for 3 weeks and he was told that these things take time. It was reported that he was told by the ophthalmic assistant that he should visit his primary health care provider in the meantime as he was being evaluated for cataract surgery. He was told that he had ptosis in both eyes. The second primary doctor mentioned it could be neurological. The patient had blood tests at the Clinic which confirmed that he probably had it by some number that's supposed to be less than 0.02 when his result was like 3.7 and then another test that was either positive or negative and he was positive. The patient went to a neurologist, he was diagnosed with myasthenia gravis in June 2025. It was reported that during his 3.5-hour surgery, along with the 3 hours it took him to wake up afterwards, there was at least 2 drugs that could cause myasthenia gravis as well as any kind of strain in the body or crisis. The patient was told that there was a good chance that the myasthenia gravis was caused by general anesthesia. The patient was immunocompromised by the drugs at that point as he had been on steroids for over a year. In February 2025, the patient started on CellCept for myasthenia gravis to get him off of the steroids, it was tapering them, but he was still on them. It was reported that he switched to Moderna from Pfizer when it was figured out that none of them worked the 6 months. It was concluded that patient had to get more than one type of immunity, but the most robust immunity was to start to dissipate after 4 months and then with the Moderna it was after 5 months so it little longer than the Pfizer. The reporter stated it seemed to be what many of the studies had shown anyway. This case was linked to US-MODERNATX, INC.-MOD-2025-789703 (E2B Linked Report).; Reporter's Comments: The benefit -risk relationship of product is not affected by this report.; Sender's Comments: US-MODERNATX, INC.-MOD-2025-789703:different patient
Hypothyroidism
Medical History/Concurrent Conditions: Heart disorder; Prostate surgery
Test Date: 2025; Test Name: blood tests; Result Unstructured Data: The blood tests confirmed patient probably had it by some number that's supposed to be less than 0.02 when patient's result was like 3.7