Report #2870485

Received Nov 4, 2025

Life-threateningHospitalizedER / ED visitOffice visit

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Overview

Sex: Female
Age: 59 yrs
State: PA
Recovered: Recovered
Vaccinated: Feb 27, 2025
Onset: Apr 1, 2025
Days to onset: 33
Hospital days: —

Vaccines (1)

Type	Name	Manufacturer	Dose	Lot	Route / Site
VARZOS	ZOSTER (SHINGRIX)	GLAXOSMITHKLINE BIOLOGICALS	2	—	IM / LA

Symptoms (5)

Biopsy skin abnormalLichenoid keratosisPulmonary embolismRashSkin disorder

Symptom narrative

Patient developed a widespread rash soon after Shingrix injection (most recent injection at the end of Februrary). She never had a similar rash in the past and has no history of lichenoid dermatitis. She was treated with topical triamcinolone cream. While her rash has completely resolved, she now has significant post-inflammatory skin changes. Of note, patient developed an unexplained pulmonary embolism in May of 2025. While we cannot say with certainty that this was secondary to Shingrix injection and while I did not see her for her embolism (she went to the emergency room for this), she had no other pre-disposing factors and no other explainable etiology for her embolism. She now takes Xarelto.

Current illness

None

Medical history

None

Other medications

N/A

Allergies

NKDA

Lab data

A punch biopsy was conducted with the following results: LICHENOID DERMATITIS, SEE COMMENT COMMENT: In the context of the clinical impression, the histopathologic findings could be compatible with a vaccine induced lichenoid eruption.