Received Nov 24, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| MMR | MEASLES + MUMPS + RUBELLA (NO BRAND NAME) | UNKNOWN MANUFACTURER | 1 | UNK | — |
Optic perineuritis; This serious case was reported in a literature article and described the occurrence of optic perineuritis in a 70-year-old male patient who received MMR (MMR vaccine) for prophylaxis. Literature Reference: On an unknown date, the patient received the 1st dose of MMR vaccine. On an unknown date, 9 weeks after receiving MMR vaccine, the patient experienced optic perineuritis (Verbatim: Optic perineuritis) (serious criteria GSK medically significant). The patient was treated with steroids. The outcome of the optic perineuritis was resolved. The reporter considered the optic perineuritis to be related to MMR vaccine. The company considered the optic perineuritis to be unrelated to MMR vaccine. Additional Information: GSK Receipt Date: 10-NOV-2025 Author reports a case of a 70-year-old male who presented to the Hospital after two episodes of self-resolving acute painless vision loss in the right eye (OD) and headaches 9?weeks after receiving the first dose of the measles, mumps, and rubella (MMR) vaccination. Magnetic resonance imaging (MRI) performed at an outside institution showed enhancement of the right optic nerve sheath suggesting optic perineuritis (OPN). Extensive laboratory investigations were negative for common infectious and inflammatory etiologies. The patient received IV steroids followed by a taper, with no recurrence. Author utilized the Bradford Hill criteria for causality to evaluate the evidence for a causal relationship between MMR vaccination and OPN, supporting post-vaccination autoimmunity as the most plausible etiology. This case highlights a rare presentation of OPN, potentially attributable to immunization at an unusual age. This article is not available for regulatory reporting due to copyright restriction.; Sender's Comments: A case of Optic perineuritis, 9 weeks after receiving MMR vaccine, in a 70-year-old male patient. Case lacks further information on medical history, concurrent conditions and concomitant medications. Based on the available information a?possible causality that the event was caused by the GSK product cannot be ascertained. Consent for further follow-up has not been received.
Comments: Magnetic resonance imaging (MRI) performed at an outside institution showed enhancement of the right optic nerve sheath suggesting optic perineuritis (OPN). Extensive laboratory investigations were negative for common infectious and inflammatory etiologies. Author utilized the Bradford Hill criteria for causality to evaluate the evidence for a causal relationship between MMR vaccination and OPN, supporting post-vaccination autoimmunity as the most plausible etiology.