Received Dec 19, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| COVID19 | COVID19 (COVID19 (PFIZER-BIONTECH)) | PFIZER\BIONTECH | 2 | — | — |
Myocarditis; This is a literature report for the following literature source(s). The SARS-CoV-2 causing COVID-19 can have serious effects on the heart with recent data suggesting acute cardiac injury in almost one fifth of COVID-19 patients. Considering the recent role out of COVID-19 vaccines to the general public there is a growing concern of COVID-19 related myocarditis being linked to the vaccine. Here, the authors present a case of a young patient who presented with symptoms of COVID-19 after his second shot of COVID-19 vaccine, with subsequent development of myocarditis. This patient is a 21-year-old male with past medical history significant of mitral valve prolapse, and resting tachycardia, presented with a 2-day history of fevers, nausea, accompanied by shortness of breath, and chest pain. Patient had his 2nd shot of Pfizer-BioNTech Covid-19 vaccine 3 days prior to admission, symptom onset was after the administration of vaccine. Vitals on admission were within normal limits, EKG did not show any acute ischemic changes, no evidence of pericarditis and or pulmonary embolism related changes. Troponins were trended, 460, 637, 832, significant for acute myocardial injury but with no evidence of MI based on character of chest pain and EKG changes. 2D echocardiogram showed Left Ventricular (LV) Ejection Fraction of 43%, with mildly reduced LV systolic function. CTA chest with IV contrast showed no aortic dissection or pulmonary embolism. Cardiac MRI showed findings suggestive of acute myocarditis. Patient was treated symptomatically, troponins trended down, with resolution of chest pain. Per discussion, myocarditis associated with the Pfizer-BioNTech Covid-19 vaccine, is a potential rare side effect. Even though a causal link has not been established. Considering the sequence of events for this patient, there is potentially a link between the two. Myocarditis has been associated with COVID-19 infection. But the link with Pfizer-BioNTech Covid-19 vaccine is less established, with few cases providing a causal link. Recent studies have started to link the two, but further investigations are necessary to better understand the causal link, and what propagates the younger population to develop myocarditis after receiving the COVID-19 Vaccine. No follow-up attempts are possible.; Sender's Comments: There is a reasonable possibility that the event myocarditis was related to BNT162b2 based on known drug safety profile. The impact of this report on the benefit/risk profile of the Pfizer product is evaluated as part of Pfizer procedures for safety evaluation, including the review and analysis of aggregate data for adverse events. Any safety concern identified as part of this review, as well as any appropriate action in response, will be promptly notified to regulatory authorities, Ethics Committees, and Investigators, as appropriate.
Medical History/Concurrent Conditions: Mitral valve prolapse; Resting tachycardia
Test Name: CTA chest with IV contrast; Result Unstructured Data: Test Result:No aortic dissection or pulmonary embolism; Test Name: COVID-19; Result Unstructured Data: Test Result:Positive; Comments: symptoms of COVID-19 after his second shot of COVID-19 vaccine; Test Name: 2D echocardiogram; Result Unstructured Data: Test Result:Left Ventricular (LV) Ejection Fraction of 43%; Comments: Mildly reduced LV systolic function; Test Name: EKG; Result Unstructured Data: Test Result:Did not show any acute ischemic changes; Comments: No evidence of pericarditis and or pulmonary embolism related changes; Test Name: Cardiac MRI; Result Unstructured Data: Test Result:Acute myocarditis; Test Name: Troponins level; Result Unstructured Data: Test Result:460, 637, 832; Comments: Significant for acute myocardial injury but with no evidence of MI; Test Name: Troponins level; Result Unstructured Data: Test Result:Trended down; Test Name: Vitals; Result Unstructured Data: Test Result:Within normal limits