Received Dec 23, 2025
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| VARZOS | ZOSTER (SHINGRIX) | GLAXOSMITHKLINE BIOLOGICALS | UNK | UNK | — |
6 months later had the worst kind of Shingles/suspected vaccination failure; 6 months later had the worst kind of Shingles/internal shingles; could not eat anything; lost 11 lbs in a week; This serious case was reported by a consumer via interactive digital media and described the occurrence of vaccination failure in a male patient who received Herpes zoster (Shingrix) for prophylaxis. On an unknown date, the patient received Shingrix. On an unknown date, 6 months after receiving Shingrix, the patient experienced vaccination failure (Verbatim: 6 months later had the worst kind of Shingles/suspected vaccination failure) (serious criteria GSK medically significant), zoster sine herpete (Verbatim: 6 months later had the worst kind of Shingles/internal shingles), unable to eat (Verbatim: could not eat anything) and weight loss (Verbatim: lost 11 lbs in a week). The outcome of the vaccination failure, unable to eat and weight loss were not reported and the outcome of the zoster sine herpete was resolving. It was unknown if the reporter considered the vaccination failure, zoster sine herpete, unable to eat and weight loss to be related to Shingrix. The company considered the vaccination failure to be unrelated to Shingrix. It was unknown if the company considered the zoster sine herpete, unable to eat and weight loss to be related to Shingrix. Additional Information: GSK Receipt Date: 18-DEC-2025 This case was reported by a patient's wife via interactive digital media. Patient had the Shingrix vaccine. 6 months later patient had the worst kind of Shingles- internal shingles and it affected patient's diaphragm and esophagus. Patient lost 11 lbs in a week because he could not eat anything, the pain was so bad. Shingles did not go to patient's liver, brain or other organs that could have killed him. Patient had one tiny little cluster of 3 blisters on the outside that left a scar. The batch number was not provided, and we are unable to contact the reporter. This case was considered as suspected vaccination failure as details regarding complete vaccination schedule and laboratory test confirming shingles were unknown at the time of reporting.; Sender's Comments: A case of Vaccination failure,6 months after receiving Shingrix, in a male patient. Causal association is indeterminate. Based on the available information a?possible causality that the event was caused by the GSK product cannot be ascertained. Consent for further follow-up has not been received.
Test Name: weight; Result Unstructured Data: (Test Result:lost 11 lbs in a week,Unit:unknown,Normal Low:,Normal High:)