Report #2881686

Overview

Sex

Male

Age

Age unknown

State

—

Recovered

Unknown

Vaccinated

—

Onset

—

Days to onset

—

Hospital days

—

Symptoms (2)

Symptom narrative

suspected vaccination failure; Herpes zoster ophthalmic; This serious case was reported by a physician via interactive digital media and described the occurrence of vaccination failure in a male patient who received Herpes zoster (Shingrix) for prophylaxis. Concurrent medical conditions included autoimmune disorder (This user has an autoimmune disorder and they tend to have reactions with medications). On an unknown date, the patient received Shingrix. On an unknown date, an unknown time after receiving Shingrix, the patient experienced vaccination failure (Verbatim: suspected vaccination failure) (serious criteria GSK medically significant) and ophthalmic herpes zoster (Verbatim: Herpes zoster ophthalmic) (serious criteria GSK medically significant). The outcome of the vaccination failure and ophthalmic herpes zoster were not reported. It was unknown if the reporter considered the vaccination failure and ophthalmic herpes zoster to be related to Shingrix. The company considered the vaccination failure and ophthalmic herpes zoster to be unrelated to Shingrix. Additional Information: GSK Receipt Date: 09-JAN-2026 The reporter stated that the report documented their clinical course, diagnostic process, and treatment, both systemic and ocular. The patient had received the Shingrix vaccinations six years earlier. The reactivation of herpes zoster after Shingrix had also been reported occasionally, despite the vaccine intended protective effect, possibly due to preexisting subclinical reactivations being unmasked. The reporter stated that the very fact that the vaccine offered protection had made the eye care professional diagnosis somewhat challenging. The reporter stated that events of HSV reactivation after Shingrix had been rare, usually self-limited, and not clinically serious. The batch number was not provided and unable to contact the reporter. This case was considered as suspected vaccination failure as details regarding completion of primary vaccination schedule, time to onset for shingles and laboratory confirmation regarding shingles were unknown at the time of reporting.; Sender's Comments: A case of Vaccination failure and Ophthalmic herpes zoster, an unknown time after receiving Shingrix, in a male patient. Causal association is indeterminate. Based on the available information a possible causality that the event was caused by the GSK product cannot be ascertained. Consent for further follow-up has not been received.

Current illness

Autoimmune disorder (This user has an autoimmune disorder and they tend to have reactions with medications)