VAERS Explorer
Back to explore

Report #2883591

Received Feb 1, 2026

Life-threateningHospitalizedOffice visit
A note on interpretation. VAERS reports are unverified and may be incomplete or coincidental. A report does not establish that a vaccine caused an event, and counts should not be used to calculate incidence or infer causation. Full disclaimer

Overview

Sex
Female
Age
43 yrs
State
CA
Recovered
Not recovered
Vaccinated
Jan 28, 2022
Onset
Apr 20, 2023
Days to onset
447
Hospital days
4

Vaccines (1)

TypeNameManufacturerDoseLotRoute / Site
COVID19COVID19 (COVID19 (PFIZER-BIONTECH))PFIZER\BIONTECHUNK—IM / LA

Symptoms (22)

Blood testCognitive disorderDevelopmental delayDysstasiaEchocardiogramElectroencephalogram abnormalEmotional distressExaggerated startle responseFeeding disorderFrustration tolerance decreasedGait inabilityGene mutationGene mutation identification test positiveInability to crawlLearning disorderLoss of personal independence in daily activitiesLumbar punctureMagnetic resonance imaging headNeurodegenerative disorderSeizureSeizure clusterSpeech disorder developmental

Symptom narrative

My 3rd baby weighing 8lbs, healthy pregnancy. I had 2 previous pregnancies before any COVID VACCINES and both children are healthy (7 years and 4 years old) and myself husband and I are not carriers of the mutation that our 3rd baby was diagnosed with and believe the COVID Vaccines.boosters caused this. Child was diagnosed with Beta-Propeller Protein-Associated Neurodegeneration (BPAN), an ultra-rare, progressive, and incurable genetic neurological disease. Symptoms and Limitations: BPAN causes severe global developmental delay, low muscle tone, poor motor control, and epilepsy. Child cannot crawl, sit unassisted, stand, walk, or feed herself. She has daily startle-triggered seizures and seizure clusters despite being on three anti-seizure medications. She has limited or absent speech, significant learning and cognitive delays, and requires constant supervision for safety. Behavioral/Emotional Impact: She experiences frustration, distress, difficulty self-soothing, sensitivity to stimulation, and dependence on caregivers for emotional regulation due to inability to communicate. Disease Course: BPAN is degenerative. Symptoms worsen over time and may include loss of skills, increasing movement disorder, rigidity, and severe intellectual disability. Prognosis: There is no cure. Treatment is supportive only. child requires full-time care and assistance with all daily living activities.

Current illness

no

Medical history

no

Other medications

Pre-natal vitamins

Allergies

no

Lab data

Overnight EEG (Electroencephalogram) ? multiple studies Purpose: Evaluate seizure activity and abnormal brain electrical activity Dates: _Initial 5-15-24 and various after at facilities__________________________ Extended / Video EEG Monitoring (Inpatient) Purpose: Capture seizure clusters and startle-triggered seizures Dates: _May 2024 __________________________ Brain MRI Purpose: Evaluate brain structure and rule out structural abnormalities Dates: _5-15-24 __________________________ Lumbar Puncture (Spinal Tap / CSF Analysis) Purpose: Evaluate for metabolic, infectious, or neurological causes Dates: __5-15-24 _________________________ Genetic Testing (Whole Exome / Targeted Gene Panel) Result: Pathogenic de novo mutation in WDR45, confirming BPAN Dates: __5-14-24 _________________________ Echocardiogram Purpose: Cardiac monitoring related to seizure medication safety Dates: ___Fall 2025________________________ Bloodwork (Routine & Medication Monitoring) Purpose: Monitor medication levels, liver function, metabolic markers Dates: _Since she was first diagnosed in 2024__________________________ Neurological Examinations (Pediatric Neurology) Purpose: Ongoing assessment of seizures, tone, development, progression Dates: Ongoing since __2024_________________ Developmental Assessments Purpose: Evaluate gross motor, fine motor, speech, and cognitive delays Dates: Ongoing since __2024_________________ Therapy Evaluations (PT / OT / Speech) Purpose: Assess functional limitations and therapy needs Dates: Ongoing since __2024_________________