Received Feb 18, 2026
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| COVID19 | COVID19 (COVID19 (PFIZER-BIONTECH)) | PFIZER\BIONTECH | 3 | FK9894 | — |
progressive multi-organ dysfunction consisten with post-COVID 19 vaccine syndrome (PCVS); This is a literature report from License Party for the following literature source(s). Other Case identifier(s): AE-022566 (BIONTECH). A 55-year-old male patient received BNT162b2 (COMIRNATY), on 20Feb2022 as dose 3 (booster), single (Lot number: FK9894) for covid-19 immunisation. The patient's relevant medical history included: "postoperative venous thromboembolism" (unspecified if ongoing); "deep venous thrombosis" (unspecified if ongoing), notes: at age 46; "pulmonary embolism" (unspecified if ongoing), notes: at age 46; "lumbar spine surgery" (unspecified if ongoing), notes: at age 46; "anticoagulation" (unspecified if ongoing), notes: completed three months. with follow-up imaging demonstrating resolution; "mild hearing loss with tinnitus" (ongoing); "mild hearing loss with tinnitus" (ongoing); "elevated blood pressure" (unspecified if ongoing), notes: intermittently, treated at times with low-dose losartan; "anxiety" (unspecified if ongoing), notes: occasional; "routine physical examinations normal" (unspecified if ongoing); "coronary calcium scoring normal" (unspecified if ongoing); "baseline Cardiac stress test normal" (unspecified if ongoing); "Benign paroxysmal positional vertigo (BPPV)" (unspecified if ongoing), notes: documented in neurology records (2022-2024).; "Intermittent dizziness" (unspecified if ongoing), notes: documented as part of the otolaryngology-related symptom history.; "painless right foot drop", start date: Feb2025 (unspecified if ongoing), notes: (Emergency Department impression: peroneal nerve injury vs L5 radiculopathy); "right elbow numbness", start date: Feb2025 (unspecified if ongoing); "cognitive fog" (unspecified if ongoing); "temperature intolerance" (unspecified if ongoing); "exercise intolerance" (unspecified if ongoing); "tightness/pain" (unspecified if ongoing), notes: progressive left-sided; "telangiectasia" (unspecified if ongoing), notes: described orange-yellow facial papules., which resolved over Fall 2021; "trunk rash" (unspecified if ongoing); "bilateral dry eye" (unspecified if ongoing); "macular scars" (unspecified if ongoing), notes: (OS; post-inflammatory/traumatic); "RPE hypopigmentation" (unspecified if ongoing), notes: retinal pigment epithelium (RPE) hypopigmentation; "choroidal neoplasm" (unspecified if ongoing), notes: (OD); "worsening vision fluctuations" (unspecified if ongoing), notes: (L>R) with intermittent horizontal diplopia, dizziness, and photophobia, with assessment documenting suspected decompensated phoria and worsened dry eye; "Night vision issues" (unspecified if ongoing); "Long COVID" (unspecified if ongoing). The patient's concomitant medications were not reported. Past drug history included: Rifaximin, reaction(s): "lack of response"; Rifaximin, reaction(s): "worsening tinnitus"; Neomycin, reaction(s): "worsening tinnitus"; Rifaximin, reaction(s): "sensorineural hearing loss"; Neomycin, reaction(s): "sensorineural hearing loss". The following information was reported: POST-ACUTE COVID-19 SYNDROME (non-serious) with onset Jun2023, outcome "not recovered", described as "progressive multi-organ dysfunction consisten with post-COVID 19 vaccine syndrome (PCVS)". Relevant laboratory tests and procedures are available in the appropriate section.; Sender's Comments: A possible contributory role of the suspect products cannot be excluded for the reported event long covid-19 based on the known safety profile and plausible temporal association.
Hearing loss; Tinnitus
Medical History/Concurrent Conditions: Anticoagulant therapy (completed three months. with follow-up imaging demonstrating resolution); Anxiety (occasional); Benign paroxysmal positional vertigo (documented in neurology records (2022-2024).); Blood pressure increased (intermittently, treated at times with low-dose losartan); Brain fog; Cardiac stress test normal; Choroidal nevus ((OD)); Computerised tomogram heart normal; Deep vein thrombosis (at age 46); Dizziness (documented as part of the otolaryngology-related symptom history.); Dry eye; Exercise tolerance decreased; Foot drop ((Emergency Department impression: peroneal nerve injury vs L5 radiculopathy)); Long COVID; Macular scar ((OS; post-inflammatory/traumatic)); Muscle tightness (progressive left-sided); Night blindness, unspecified; Numbness in hand; Physical examination normal; Pulmonary embolism (at age 46); Rash trunk; Retinal disorder (retinal pigment epithelium (RPE) hypopigmentation); Surgery (at age 46); Telangiectasia (described orange-yellow facial papules. which resolved over Fall 2021); Temperature intolerance; Venous thromboembolism; Vision abnormal aggravated ((L>R) with intermittent horizontal diplopia, dizziness, and photophobia, with assessment documenting suspected decompensated phoria and worsened dry eye)
Test Date: 20251112; Test Name: TNF-alpha; Result Unstructured Data: Test Result:1.2 pg/mL; Comments: reference 3.7-11.0; Test Date: 20240620; Test Name: tumor necrosis factor-alpha (TNF-alpha); Result Unstructured Data: Test Result:remained within reference ranges; Test Date: 20220322; Test Name: audiologic testing; Result Unstructured Data: Test Result:high-frequency hearing loss; Comments: with bilateral sensorineural hearing loss that was asymmetric and worse in the right ear (right moderate to severe; left mild to moderate).; Test Name: biopsies; Test Result: Negative ; Test Name: biopsies; Result Unstructured Data: Test Result:moderate to pronounced perivascular; Comments: periadnexal, and perineural inflammatory infiltration, composed of lymphocytes, macrophages, mast cells, and eosinophils By 1,364 days post-vaccination; Test Name: duodenal biopsies; Test Result: Negative ; Test Name: Esophageal biopsies; Test Result: Negative ; Test Date: 20250424; Test Name: Grover's lesion trunk biopsy (PCR + histology/IHC); Result Unstructured Data: Test Result:SARS-CoV-2 Spike S1 subunit positive; Comments: in endothelial cells; Spike S1 subunit positive in perivascular macrophages; nucleocapsid not detected Days since last vaccine: 1160 days; Test Date: 20250722; Test Name: Grover's lesion trunk biopsy (PCR + histology/IHC); Result Unstructured Data: Test Result:SARS-CoV-2 Spike S1 subunit positive; Comments: in perivascular macrophages; nucleocapsid not detected Days since last vaccine:1249 days; Test Date: 20251114; Test Name: Grover's lesion trunk biopsy (PCR + histology/IHC); Result Unstructured Data: Test Result:Vaccine plasmid DNA positive; Comments: (SV40, ori 1, ori 2: all positive); vaccine plasmid DNA fragments positive (sequence 1; sequence 2; sequence 3); SARS-CoV-2 Spike S1 subunit positive in nerve fibers; Spike S1 subunit positive in endothelial cells; Spike S1 subunit positive in perivascular macrophages; nucleocapsid not detected Days since last vaccine: 1,364 days; Test Name: Serial skin biopsies; Result Unstructured Data: Test Result:all from truncal skin within areas of clinically; Comments: active Grover's disease were nucleocapsid negative and demonstrated persistent spike protein deposition in endothelial cells and macrophages by automated immunohistochemistry with histopathologic correlation; Test Name: Serial skin biopsies; Result Unstructured Data: Test Result:Spike protein was also found in nerve fibers; Comments: at 1,364 days. The 1,364-day skin biopsy contained multiple plasmid DNA elements, including spike gene sequences (S1-S3), ori1/ori2, and the SV40 enhancer, confirming durable retention of vaccine-derived DNA in somatic tissue by PCR amplification with agarose gel electrophoresis and Sanger sequencing.; Test Date: 20250414; Test Name: Serial skin biopsies; Result Unstructured Data: Test Result:transient acantholytic dermatosis; Comments: left lateral abdomen (Grover's disease); Test Date: 202402; Test Name: IgA; Test Result: 326 mg/dl; Comments: elevated secretory reference range 30-275; Test Name: Transcriptomic profiling of whole blood; Result Unstructured Data: Test Result:blood highlighted oxidative stress; Comments: vascular activation, and nuclear fragility; Test Name: B-type natriuretic peptide (BNP); Result Unstructured Data: Test Result:Unknown results; Comments: From 2021-2024, 13, which were documented as consistently within reference range, with the exception of low anion gap; Test Date: 20240228; Test Name: Capsule endoscopy; Result Unstructured Data: Test Result:small scattered non-bleeding angioectasia; Comments: without active bleeding.; Test Date: 20251112; Test Name: CCL5 (RANTES); Result Unstructured Data: Test Result:12,361.3 pg/mL; Comments: reference 7.2-11,800 elevations; Test Date: 20221017; Test Name: colonoscopy; Result Unstructured Data: Test Result:diverticulosis and multiple colon polyps; Comments: (one 15 mm cecal polyp and nine 4-8 mm polyps in the transverse/ascending colon).; Test Date: 2024; Test Name: colonoscopy; Test Result: Negative ; Test Date: 20260123; Test Name: colonoscopy; Result Unstructured Data: Test Result:diverticulosis (sigmoid and descending colon); Comments: and polyps (one 6 mm sessile polyp in the ascending colon and eight diminutive sessile polyps across the sigmoid, descending, transverse colon, and cecum); Test Date: 20211109; Test Name: Chest CT; Result Unstructured Data: Test Result:multiple small bilateral pulmonary emboli; Comments: prompting hospitalization, specialty referral, and initiation of anticoagulation; Test Date: 20220222; Test Name: Chest CT; Result Unstructured Data: Test Result:demonstrated resolution of the pulmonary emboli; Comments: and described clear lungs without inflammatory findings. Symptoms persisted and broadened across multiple systems.; Test Date: 202207; Test Name: Chest CT; Result Unstructured Data: Test Result:no recurrent pulmonary emboli; Comments: but demonstrated new scattered semi-solid ground-glass opacities described as suggestive of infection or inflammation; the patient denied infectious symptoms at that time; Test Date: 20241205; Test Name: cytokines; Result Unstructured Data: Test Result:continued elevation; Comments: (1,038 days post-vaccination); Test Name: transthoracic echocardiograms; Result Unstructured Data: Test Result:normal cardiac chamber size; Comments: Between 2022 and 2024 preserved systolic function; Test Name: serial ambulatory rhythm monitoring; Result Unstructured Data: Test Result:occasional premature atrial contractions (PACs); Comments: occasional premature ventricular contractions (PVCs), and brief self-terminating supraventricular tachycardia (SVT). Between 2022 and 2024; Test Date: 20230528; Test Name: serial ambulatory rhythm monitoring; Result Unstructured Data: Test Result:Intermittent Idioventricular Rhythm; Comments: on a home monitoring device during an episode of severe chest pain; the rhythm strip was verified by a medical provider; Test Date: 20230629; Test Name: EMG/NCS; Result Unstructured Data: Test Result:Normal; Comments: with repetitive nerve stimulation; Test Date: 20221017; Test Name: Upper endoscopy; Result Unstructured Data: Test Result:an irregular Z-line at 40 cm from the incisors; Comments: diffuse mild gastric erythema, and a 2 cm sliding hiatal hernia; Test Date: 20230517; Test Name: Upper endoscopy; Result Unstructured Data: Test Result:no hiatal hernia, an irregular Z-line; Comments: Hill grade II valve, no esophagitis, and gastritis, with normal duodenum and jejunum; Test Name: complete blood counts (CBCs); Result Unstructured Data: Test Result:Unknown results; Comments: From 2021-2024, he underwent greater than 40, which were documented as consistently within reference range, with the exception of low anion gap; Test Date: 20220801; Test Name: Gastroenterology evaluation; Result Unstructured Data: Test Result:hoarseness/dry throat; Comments: abdominal pain, chest pain, bloating, belching, gas, and change in bowel habits.; Test Date: 20240130; Test Name: gene-expression biomarker; Result Unstructured Data: Test Result:NR3C1, GLUD1, and TREM2 were flagged; Test Name: Genetic testing; Result Unstructured Data: Test Result:no pathogenic variants were identified; Comments: (Invitae Adenomatous Polyposis Panel and Invitae Multi-Cancer testing with RNA analysis); Test Date: 20251112; Test Name: GM-CSF; Result Unstructured Data: Test Result:3.6 pg/mL; Comments: reference 5.8-77.0 reduced levels; Test Date: 20240620; Test Name: granulocyte macrophage colony-stimulating factor; Result Unstructured Data: Test Result:3.6; Comments: reduced (reference range: 5.8-77.0); Test Date: 20241205; Test Name: granulocyte macrophage colony-stimulating factor; Result Unstructured Data: Test Result:2.4; Comments: remained suppressed or low; Test Date: 20211028; Test Name: heart rate; Result Unstructured Data: Test Result:208 bpm; Test Date: 20251112; Test Name: IL-2; Result Unstructured Data: Test Result:1.1 pg/mL; Comments: reference 1.6-7.0 reduced levels; Test Date: 20250910; Test Name: blood-based immune/inflammatory biomarker assay; Result Unstructured Data: Test Result:NR3C1, GLUD1, and TREM2 were flagged; Test Name: ELISA; Result Unstructured Data: Test Result:free (withheld) spike protein in plasma; Comments: At 1,173 days post vaccination,(129.0 +-4.1 fg/mL) and in circulating exosomes (11.6 +- 0.1 fg/mL). accompanied by markedly elevated spike-specific IgG4 (354.4 +- 22.4 ng/mL).; Test Name: ELISA; Result Unstructured Data: Test Result:320.2 +- 4.4 ng/mL; Comments: By 1,284 days post-vaccination, IgG4 remained prominently elevated.; Test Name: blood-based immune testing; Result Unstructured Data: Test Result:identified detectable SARS-CoV-2 S1 protein; Comments: within classical and non-classical monocyte subsets with associated cytokine and immune marker abnormalities; Test Date: 20251112; Test Name: IFN-gamma; Result Unstructured Data: Test Result:15.0 pg/mL; Comments: reference 1.8 3.5 elevations; Test Date: 20240620; Test Name: interferon-gamma (IFN-gamma); Result Unstructured Data: Test Result:27.8; Comments: (reference range: 1.8-3.5),; Test Date: 20241205; Test Name: interferon-gamma (IFN-gamma); Result Unstructured Data: Test Result:17.0; Test Date: 20251112; Test Name: IL 6; Result Unstructured Data: Test Result:1.2 pg/mL; Comments: reference 1.4-3.0 reduced levels; Test Date: 20251112; Test Name: IL-10; Result Unstructured Data: Test Result:2.7 pg/mL; Comments: reference 0.7-1.2 elevations; Test Date: 20251112; Test Name: IL-13; Result Unstructured Data: Test Result:9.2 pg/mL; Comments: reference 1.5-6.1 elevations; Test Date: 20251112; Test Name: IL-4; Result Unstructured Data: Test Result:24.9 pg/mL; Comments: reference 2.3-6.2 elevations; Test Date: 20251112; Test Name: IL-8; Result Unstructured Data: Test Result:3.3 pg/mL; Comments: reference 5.4-21.0 reduced levels; Test Date: 20240620; Test Name: interleukin-10 (IL-10); Result Unstructured Data: Test Result:4.5; Comments: (reference range: 0.7-1.2),; Test Date: 20241205; Test Name: interleukin-10 (IL-10); Result Unstructured Data: Test Result:3.3; Test Date: 20240620; Test Name: interleukin-13 (IL-13); Result Unstructured Data: Test Result:13.7; Comments: (reference range: 1.5-6.1),; Test Date: 20241205; Test Name: interleukin-13 (IL-13); Result Unstructured Data: Test Result:12.1; Test Date: 20240620; Test Name: interleukin-4 (IL-4); Result Unstructured Data: Test Result:14.2; Comments: (reference range: 2.3-6.2); Test Date: 20241205; Test Name: interleukin-4 (IL-4); Result Unstructured Data: Test Result:15.6; Test Date: 20241205; Test Name: interleukin-6 (IL-6); Result Unstructured Data: Test Result:0.5; Comments: remained suppressed or low; Test Date: 20241205; Test Name: interleukin-8 (IL-8); Result Unstructured Data: Test Result:3.3; Comments: remained suppressed or low; Test Date: 202502; Test Name: additional screening; Test Result: Negative ; Comments: for myasthenia gravis and giant cell arteritis; Test Date: 202307; Test Name: breath testing; Result Unstructured Data: Test Result:a hydrogen rise greater than wqual 20 ppm; Comments: within 100 minutes for small intestinal bacterial overgrowth (SIBO) in Jul2023 using a lactulose-based (withheld) protocol demonstrated consistent with SIBO; Test Name: D-dimer; Result Unstructured Data: Test Result:1.71 ug/mL FEU; Comments: elevated reference range less than 0.22 µg/mL FEU; Test Date: 20231009; Test Name: IBS-Smart testing; Result Unstructured Data: Test Result:anti-CdtB and anti-vinculin antibodies not elevate; Test Date: 20250925; Test Name: isoenzyme testing; Result Unstructured Data: Test Result:serial amylase/lipase elevations; Comments: isoenzyme testing supported a pancreatic source.; Test Date: 20240620; Test Name: Long Hauler & COVID-19 S1 Immune Subset Panel; Result Unstructured Data: Test Result:S1-positive monocytes detected; Comments: Days since last vaccine: 852 days (CD14loCD16+ nonclassical 3.36 (reference range: 0.00); CD14++CD16- classical 0.77) (reference range: 0.00); cytokine abnormalities; Long Hauler Index 1.96 (elevated) (reference range: less than equal 0.70).; Test Date: 20241205; Test Name: Long Hauler & COVID-19 S1 Immune Subset Panel; Result Unstructured Data: Test Result:0.25; Comments: Days since last vaccine: 1020 days Persistent cytokine abnormalities S1-positive monocytes no longer detected.; Test Date: 20251112; Test Name: Long Hauler & COVID-19 S1 Immune Subset Panel; Result Unstructured Data: Test Result:Persistent cytokine abnormalities; Comments: VEGF increased; Long Hauler Index 1.10 (elevated) Days since last vaccine: 1,362 days; Test Date: 20251112; Test Name: Long Hauler Index; Result Unstructured Data: Test Result:1.10; Comments: reference less than equal 0.70 elevated; Test Date: 20250819; Test Name: Multi-Omic Analysis; Result Unstructured Data: Test Result:Structural genomic instability; Comments: redox and mitochondrial stress, endothelial activation and a proteomic signature of chronic inflammation and vascular injury. Days since last vaccine: 1277 days; Test Date: 202208; Test Name: Multiple evaluations; Result Unstructured Data: Test Result:laryngospasm; Comments: reflux without esophagitis, and oropharyngeal dysphagia, with additional documentation of vocal fold inflammation and voice dysphonia; Test Date: 2021; Test Name: outpatient evaluation; Result Unstructured Data: Test Result:Unknown results; Test Date: 20240620; Test Name: soluble CD40 ligand (sCD40L); Result Unstructured Data: Test Result:remained within reference ranges; Test Date: 202201; Test Name: thrombophilia evaluations; Result Unstructured Data: Test Result:unremarkable; Test Date: 202212; Test Name: thrombophilia evaluations; Result Unstructured Data: Test Result:unremarkable; Test Name: lab tests; Result Unstructured Data: Test Result:low free testosterone; Comments: with normal total testosterone (Sex hormone binding globulin was normal).; Test Date: 20240206; Test Name: laryngology evaluation; Result Unstructured Data: Test Result:mild to moderate vocal fold atrophy; Comments: (videostroboscopy) documented; Test Date: 20251112; Test Name: CCL3 (MIP 1alpha); Result Unstructured Data: Test Result:2.2 pg/mL; Comments: reference 3.5-33.0 reduced levels; Test Date: 20240620; Test Name: CCL3 (MIP-1alpha); Result Unstructured Data: Test Result:2.2; Comments: reduced (reference range: 3.5-33.0); Test Date: 20241205; Test Name: CCL3 (MIP-1alpha); Result Unstructured Data: Test Result:2.2; Comments: remained suppressed or low; Test Name: MRI; Result Unstructured Data: Test Result:myocarditis; Comments: delayed MRI; Test Name: MRI; Result Unstructured Data: Test Result:multilevel degenerative disc disease; Comments: (cervical/thoracic/lumbar) with moderate-severe canal narrowing at C5-C6, osseous vertebral hemangiomas (T1/T3 +- T4), bilateral hip cartilage loss, and mild left hamstring tendinosis; shoulder MRI reported rotator cuff tendinopathy with near-full thickness supraspinatus tear.; Test Date: 20240409; Test Name: cardiac MRI; Result Unstructured Data: Test Result:found the presence of inflammation; Comments: and mild scarring consistent with COVID-19 vaccine-induced myocarditis. . A comprehensive genetic profile for arrhythmias and cardiomyopathies was negative.; Test Name: comprehensive metabolic panels (CMPs); Result Unstructured Data: Test Result:Unknown results; Comments: From 2021-2024, he underwent greater than40, which were documented as consistently within reference range, with the exception of low anion gap; Test Name: High-resolution manometry; Result Unstructured Data: Test Result:100% ineffective esophageal motility; Comments: 60% failed swallows, 40% weak swallows).; Test Name: Esophagram; Result Unstructured Data: Test Result:contrast stasis; Test Date: 2021; Test Name: chest pain; Result Unstructured Data: Test Result:2/10; Comments: During fall 2021, he developed persistent low-grade; Test Date: 20250815; Test Name: PCR assays; Test Result: Negative ; Comments: for Babesia and Bartonella (withheld) Lyme Panel, (withheld), and Lyme PCR testing were non-reactive.; Test Name: PSA tests; Test Result: Negative ; Comments: Between 2022-2025; Test Date: 20250507; Test Name: Plasma/PBMC testing; Result Unstructured Data: Test Result:129.0 +- 4.1 fg/mL; Comments: Spike proteins in plasma Spike proteins in exosomes 11.6 +- 0.1 fg/mL); IgG4 spike protein Ab (354.4 +- 22.4 ng/mL). Days since last vaccine: 1173 days By 1,284 days post-vaccination, spike protein was no longer detectable in either plasma or exosomes; Test Date: 20250826; Test Name: Plasma/PBMC testing; Result Unstructured Data: Test Result:Plasmid DNA in PBMC positive; Comments: (ori 1, 2); vaccine mRNA in exosomes positive (S1 and S2 SPIKE sequence); IgG4 spike protein Ab elevated 320.2 +- 4.4 ng/mL Days since last vaccine: 1284 days, spike protein was no longer detectable in either plasma or exosomes.; Test Date: 20240508; Test Name: Nucleocapsid & Spike Antibodies; Result Unstructured Data: Test Result:Nucleocapsid negative; Comments: Days since last vaccine:809 days spike antibody greater than250 U/mL(above assay upper reporting limit) across five separate time points spanning 809-1,433 days post-vaccination, confirmed by three independent laboratories; Test Date: 20240613; Test Name: Nucleocapsid & Spike Antibodies; Result Unstructured Data: Test Result:Nucleocapsid negative; Comments: spike antibody 5,579 U/mL (elevated) Days since last vaccine: 845 days; Test Date: 20241223; Test Name: Nucleocapsid & Spike Antibodies; Result Unstructured Data: Test Result:Nucleocapsid negative; Comments: Days since last vaccine:1038 days spike antibody 5,136 U/mL (elevated); Test Date: 20250925; Test Name: Nucleocapsid & Spike Antibodies; Result Unstructured Data: Test Result:Nucleocapsid negative; Comments: spike antibody 4,130 U/mL (elevated) Days since last vaccine: 1,314 days; Test Date: 20260123; Test Name: Nucleocapsid & Spike Antibodies; Result Unstructured Data: Test Result:Nucleocapsid negative; Comments: spike antibody 4,553 U/mL (elevated) Days since last vaccine: 1,433 days; Test Name: SARS-CoV-2 antibody test; Result Unstructured Data: Test Result:4,553 IU/ml; Comments: elevated spike antibody levels 1,433 days after the final vaccination.; Test Name: RT-PCR; Result Unstructured Data: Test Result:derived spike mRNA within circulating exosomes; Comments: at 1,284 days post-vaccination, whereas PBMC RNA remained negative following DNase-treated extraction and amplicon-specific PCR targeting three spike ORF regions (S1-S3).; Test Name: serology; Result Unstructured Data: Test Result:unexpected results; Comments: results prompted expanded immune and tissue-based testing for spike- and vaccine-derived components; Test Name: serology; Result Unstructured Data: Test Result:elevated spike-specific IgG4 concentrations; Comments: (354.4 +- 22.4 ng/mL and 320.2 +- 4.4 ng/mL, respectively), consistent with ongoing antigenic stimulation and an immune-tolerance skewed response.; Test Date: 20250507; Test Name: serology; Result Unstructured Data: Test Result:tick-borne pathogens was identified; Test Date: 202402; Test Name: stool analyses; Result Unstructured Data: Test Result:increased Bacteroides family; Comments: with decreased Bifidobacterium. short-chain fatty acid abnormalities (decreased acetate %, increased butyrate %, and increased valerate %).; Test Date: 2024; Test Name: stool analyses; Result Unstructured Data: Test Result:loss of normal enteric flora; Test Name: exercise stress tests and stress echocardiograms; Result Unstructured Data: Test Result:normal; Comments: Between 2022 and 2024 electrocardiographically and echocardiographically. but clinically symptomatic (chest pain, dyspnea, dizziness, and prolonged heart rate recovery);; Test Name: troponin measurements; Result Unstructured Data: Test Result:Unknown results; Comments: From 2021-2024, he underwent greater than40, which were documented as consistently within reference range, with the exception of low anion gap; Test Date: 20240509; Test Name: duplex venous ultrasound of the left lower extremity; Result Unstructured Data: Test Result:mild venous reflux (greater than 500 ms); Comments: in the left common femoral, femoral, and great saphenous veins with associated varicosities originating from the great saphenous vein, and no evidence of acute or chronic DVT; Test Name: Urine proteomics; Result Unstructured Data: Test Result:systemic inflammation; Comments: using quantitative mass spectrometry, with complement overactivation (CFH), redox imbalance (PRDX1), and sustained antibody responses, supported by risk alleles HLA-B07:02 and DRB1 11:04.; Test Date: 20250917; Test Name: Urine proteomics; Result Unstructured Data: Test Result:Systemic inflammatory proteomic signature; Comments: consistent with immune activation and vascular leakage (non-renal) Days since last vaccine: 1306 days; Test Name: urine tests; Test Result: Negative ; Comments: Between 2022-2025; Test Date: 20240620; Test Name: vascular endothelial growth factor (VEGF); Result Unstructured Data: Test Result:14.2; Comments: (reference range: 2.0-12.3).; Test Date: 20241205; Test Name: VEGF; Result Unstructured Data: Test Result:10.6; Comments: normalization; Test Date: 20251112; Test Name: VEGF; Result Unstructured Data: Test Result:15.4 pg/mL; Comments: reference 2.0-12.3 elevations; Test Date: 20220405; Test Name: Visual evaluation; Result Unstructured Data: Test Result:vision fluctuation; Comments: and headaches (symptoms reported as beginning 2 months prior), along with dryness and decreased vision; Test Date: 202405; Test Name: Visual evaluation; Result Unstructured Data: Test Result:bilateral retinal hemorrhages; Comments: included left eye pain and vision described as "off," (superior; resolving), dry eye, and blepharitis; Test Name: Body weight; Result Unstructured Data: Test Result:50 lbs; Comments: from Apr2022 to Apr2024 (21% of body weight) and was not on a weight-loss medication.; Test Name: Whole-genome sequencing structural variant analysis; Result Unstructured Data: Test Result:widespread genomic instability; Comments: at 1,277 days post vaccination, with large duplications and deletions affecting EGFR, MYC, ERBB2, and ETV6/RUNX1, while RNA-DNA comparison showed RNA-only variants in ribosomal, NMD, small-RNA, epigenetic, and TP53 pathways