Received Mar 10, 2026
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| PPV | PNEUMO (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
| PPV | PNEUMO (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
| PPV | PNEUMO (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
suboptimal pneumococcal vaccine protection; This literature marketed report has been received from the authors of a published literature article, titled as stated above and refers to a 61-year-old male with chronic rhinosinusitis, nasal polyposis, asthma, developmental delay, schizophrenia, recurrent infections, with progressive hearing loss, nasal obstruction, and poorly controlled asthma. Childhood history included recurrent otitis media requiring tympanostomy tubes, tonsillectomy, allergic rhinosinusitis, and ineffective allergen immunotherapy. Allergy testing was positive for common environmental allergens. Imaging revealed severe pansinusitis, extensive nasal polyposis, and superimposed allergic fungal sinusitis. Immunologic evaluation showed normal immunoglobulin levels, mild CD4+ T-cell and moderate CD19+ B-cell lymphopenia, and thrombocytopenia. Recurrent infections, including otitis media and sinusitis, were misattributed to allergic rhinitis and refractory asthma, and psychiatric symptoms to schizophrenia. Fluorescence in situ (FISH) analysis identified a 22q11.2 microdeletion, confirming the diagnosis of partial DiGeorge syndrome. On an unknown date, the patient was vaccinated with a dose of unspecified pneumococcal vaccine (manufacturer unknown) (dose, route of administration, anatomical location, lot # and expiration date were not provided) for prophylaxis. Since an unknown date, pneumococcal vaccine protection was suboptimal (vaccination failure). A copy of the published article is attached as further documentation of the patient's experience. Literature report: Lot # is being requested and will be submitted if received.
Allergy test positive; DiGeorge's syndrome (developmental delay, progressive hearing loss, psychiatric symptoms (misattributed to schizophrenia), chronic rhinosinusitis, recurrent infections, including otitis media and sinusitis,); Lymphopenia; Nasal polyps; Thrombocytopenia
Medical History/Concurrent Conditions: Antiallergic therapy (ineffective); Tonsillectomy
Test Name: immunoglobulin levels; Result Unstructured Data: normal