Received Mar 24, 2026
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| PPV | PNEUMO (PNEUMOVAX) | MERCK & CO. INC. | UNK | — | — |
She also had poor response to Pneumovax.; Literature Report. This literature marketed report has been received from the authors of a published literature article, titled as stated above and refers to a 3-year-old female patient. She had a known history of Jacobsen Syndrome and was brought into the hospital following recurring episodes of epistaxis and abscesses. She was born at term, to non-consanguineous parents, and had an unremarkable prenatal course. The patient was born with dysmorphic features commonly associated with JS. During the hospital encounter, she developed multiple abscesses on her inner thigh, gluteal region and abdomen. Diagnosis of JS was confirmed. Immunological studies included: neutrophil oxidative burst, humoral panel, and quantitative immunoglobulins. Neutrophil oxidative burst/ dihydrohodamine (DHR) assay was normal. Evaluation of humoral immunity was notable for low pneumococcal titers. The immunoglobulin panel showed low immunoglobulin M (IgM) levels. On an unknown date, the patient was vaccinated with Pneumococcal Vaccine, Polyvalent (23-valent) (PNEUMOVAX) (dose, route of administration, anatomical location, lot # and expiration date were not provided) for prophylaxis. On an unknown date, she had poor response to Pneumococcal Vaccine, Polyvalent (23-valent) (PNEUMOVAX) (Vaccination failure). A copy of the published article is attached as further documentation of the patient's experience.
Jacobsen syndrome (patient born with dysmorphic features commonly associated with JS.)
Test Name: pneumococcal titers.; Result Unstructured Data: low pneumococcal titers; Test Name: immunoglobulin panel; Result Unstructured Data: low immunoglobulin M (IgM) levels.