Received Apr 22, 2026
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| HIBV | HIB (NO BRAND NAME) | UNKNOWN MANUFACTURER | UNK | — | — |
invasive Hib infections; fever; bilateral lower extremity swelling; Vaccination failure; Case Report: Since the introduction of the Haemophilus influenzae serotype B (Hib) conjugate vaccine became available in the 1980s, invasive Hib infections have decreased significantly among fully vaccinated children (Soeters, Slack). This case describes an unusual presentation of extensive invasive Hib disease in a fully immunized 10-month-old male with no significant past medical history. The patient presented with persistent fever, bilateral lower extremity swelling, and refusal to move all extremities. Magnetic resonance imaging (MRI) revealed widespread involvement of the bilateral hips and lower extremities, necessitating orthopedic surgical intervention. Blood and tissue cultures confirmed Hib on serotyping, while dissemination studies were negative for cardiac involvement or thrombosis. The patient was empirically started on vancomycin and cefepime, later narrowed to ampicillin based on bacterial speciation and susceptibility. Subsequent immunologic work-up was unremarkable and did not suggest an underlying immunodeficiency that would explain an inadequate vaccine response. A peripherally inserted central catheter (PICC) was placed, and he was discharged on intravenous ceftriaxone. After PICC dislodgement, therapy was transitioned to high-dose oral amoxicillin to complete a four-week antibiotic course. He showed favorable recovery with follow-up in a combined orthopedic-infectious diseases clinic. This case report underscores the importance of maintaining a broad differential diagnosis. Invasive Hib infections can still occur in immunocompetent individuals despite adequate vaccination, highlighting the need to consider alternate sources and causative organisms that are usually prevented by vaccines. Initial information received on 02-Mar-2026 via other health care professional regarding an unsolicited valid serious case issued from a literature article. This case involves 10-month-old male patient who experienced Invasive Hib infections (Haemophilus infection) after receiving haemophilus type b (HIB) vaccine (Latency: unknown). The patient's past medical treatment(s), vaccination(s) and family history not provided. On an unknown date, the patient received influenzae serotype B (Hib) vaccine (Dose, route, formulation: Unknown) The patient had no significant past medical history. The patient presented with persistent fever (pyrexia), bilateral lower extremity swelling, and refusal to move all extremities. Magnetic resonance imaging (MRI) revealed widespread involvement of the bilateral hips and lower extremities (Peripheral swelling), necessitating orthopedic surgical intervention. Blood and tissue cultures confirmed Hib on serotyping, while dissemination studies were negative for cardiac involvement or thrombosis. The patient was empirically started on vancomycin and cefepime, later narrowed to ampicillin based on bacterial speciation and susceptibility. Subsequent immunologic work-up was unremarkable and did not suggest an underlying immunodeficiency that would explain an inadequate vaccine response. A peripherally inserted central catheter (PICC) was placed, and he was discharged on intravenous ceftriaxone. After PICC dislodgement, therapy was transitioned to high-dose oral amoxicillin to complete a four-week antibiotic course. He showed favorable recovery with follow-up in a combined orthopedic-infectious diseases clinic. This case report underscores the importance of maintaining a broad differential diagnosis. Invasive Hib infections can still occur in immunocompetent individuals despite adequate vaccination, highlighting the need to consider alternate sources and causative organisms that are usually prevented by vaccines. This case describes an unusual presentation of extensive invasive Hib disease in a fully immunized patient. Information regarding batch number and expiration date corresponding to the one at time of event occurrence was requested. Seriousness criteria: Hospitalization Action taken: Not applicable Corrective treatment: ampicillin, ceftriaxone and amoxicillin Outcome: Recovered/Resolved Reporter s causality: Related
Test Name: Magnetic resonance imaging (MRI); Result Unstructured Data: revealed widespread involvement of the bilateral hips and lower extremities, necessitating orthopedic surgical intervention.; Test Name: Blood and tissue cultures; Result Unstructured Data: confirmed Hib on serotyping, while dissemination studies were negative for cardiac involvement or thrombosis.; Test Name: Blood and tissue cultures; Result Unstructured Data: confirmed Hib on serotyping, while dissemination studies were negative for cardiac involvement or thrombosis.; Test Name: immunologic work-up; Result Unstructured Data: was unremarkable