Received Apr 29, 2026
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| VARZOS | ZOSTER (SHINGRIX) | GLAXOSMITHKLINE BIOLOGICALS | 1 | Z3H93 | IM / LA |
| VARZOS | ZOSTER (SHINGRIX) | GLAXOSMITHKLINE BIOLOGICALS | 2 | UNK | — |
she had knee replacement for arthritis in 2025; Inappropriate schedule of vaccine administered/ never received her second dose; This serious case was reported by a consumer via call center representative and described the occurrence of arthritis in a 72-year-old female patient who received Herpes zoster (Shingrix) (batch number Z3H93, expiry date 31-JUL-2024) for prophylaxis. Co-suspect products included Herpes zoster (Shingrix) for prophylaxis. Previously administered products included Flu vaccine (received every year) and COVID 19 vaccine (received every year). On 28-MAR-2023, the patient received the 1st dose of Shingrix (intramuscular, left arm). On an unknown date, the patient received the 2nd dose of Shingrix. On an unknown date, an unknown time after receiving Shingrix and not applicable after receiving Shingrix, the patient experienced arthritis (Verbatim: she had knee replacement for arthritis in 2025) (serious criteria clinically significant/intervention required) and incomplete course of vaccination (Verbatim: Inappropriate schedule of vaccine administered/ never received her second dose). The outcome of the arthritis was not reported. It was unknown if the reporter considered the arthritis to be related to Shingrix. The company considered the arthritis to be unrelated to Shingrix. Additional Information: GSK Receipt Date: 20-APR-2026 The patient self-reported this case. The reporter stated that the patient had never received her second dose. The patient reported that in 2025 (no specific date provided) she had undergone a knee replacement for arthritis, and it was unknown whether this condition was pre-existing prior to the first dose of Shingrix. The patient reported that had been overwhelmed due to caring for her family.; Sender's Comments: A case of Arthritis, on an unknown time after vaccination with 1st dose of Shingrix and not applicable for 2nd dose of Shingrix, in a 72-year-old female patient. Based on the available information a possible causality that the event was caused by GSK vaccine product cannot be ascertained. Consent for further follow up has not been received. The company has assessed that the event Arthritis was not caused by the study vaccine Shingrix (2nd dose).