Received May 15, 2026
| Type | Name | Manufacturer | Dose | Lot | Route / Site |
|---|---|---|---|---|---|
| HEPA | HEP A (NO BRAND NAME) | UNKNOWN MANUFACTURER | 1 | UNK | IM / RL |
| MMR | MEASLES + MUMPS + RUBELLA (NO BRAND NAME) | UNKNOWN MANUFACTURER | 1 | UNK | SC / RA |
| PNC13 | PNEUMO (PREVNAR13) | PFIZER\WYETH | 1 | UNK | IM / LL |
| VARCEL | VARICELLA (NO BRAND NAME) | UNKNOWN MANUFACTURER | 1 | UNK | SC / LA |
cellulitis of hand post dog bite; This 16-month-old male subject was enrolled in a blinded study titled A Phase 3a, observer-blind, randomized, controlled study to evaluate the safety of an investigational varicella vaccine compared with Varivax, administered as a first dose to healthy children 12 to 15 months of age. The subject received the 1st dose of Varicella VNS vs Varivax (subcutaneous, left deltoid) on 22-DEC-2025 15:40, for prophylaxis. The subject received the 1st dose of MMR vaccine (subcutaneous, right deltoid) .5 ml on 22-DEC-2025 15:40, for prophylaxis. The subject received the 1st dose of Hepatitis A vaccine (intramuscular, right thigh) .5 ml on 22-DEC-2025 15:40, for prophylaxis. The subject received the 1st dose of Prevnar 13 (intramuscular, left thigh) .5 ml on 22-DEC-2025 15:40, for prophylaxis. On 06-MAY-2026, 135 days after receiving Varicella VNS vs Varivax, MMR vaccine, Hepatitis A vaccine and Prevnar 13, the subject developed moderate - grade 2 cellulitis of hand (Verbatim: cellulitis of hand post dog bite). Serious criteria included hospitalization. The outcome of cellulitis of hand was resolving. Relevant Tests: On un-MAY-2026 MRI (Magnetic Resonance Imaging) hand right wow contrast Impression:1. Extensive dorsal cellulitis of the hand and wrist, with minimal superficial fascial fluid. No drainable abscess noted. 2. No evidence of osteomyelitis, nor septic joint. On un-MAy-2026 Ultrasound (U/S) shows a complex abscess with physical examination findings of fluctuance or induration.. The investigator considered that there was no reasonable possibility that the cellulitis of hand may have been caused by Varicella VNS vs Varivax, MMR vaccine, Hepatitis A vaccine and Prevnar 13. The company considered that there was no reasonable possibility that the cellulitis of hand may have been caused by Varicella VNS vs Varivax, MMR vaccine, Hepatitis A vaccine and Prevnar 13. Swelling of the hand after contact with an unvaccinated 6-week-old puppy yesterday. Subject parents were unsure if it was a scratch versus bite and noted a break in the skin without pus. Subject parents specifically raised concern about 1 episode of emesis ("subject already- threw up too, so. We're not sure if, i think we should go to ER (emergency room) or to make sure"), but elected observation and office visit first. Swelling was first noticed in the finger this morning, then rapidly progressed to involve the entire hand within hours based on parental report. No fever. The child vomited once today. Subject was moving the wrist/hand and did not cry with palpation. No medications had been given for the swelling yet. Immunizations, including dtap (tetanus), were up to date. Subject patient's hand appeared normal at daycare drop-off at 0730, with swelling noted before 0900 while eating breakfast, increasing in size and tenderness through the morning, localizing to below the wrist. There were two transient blisters on the pinky and hand dorsum, that spontaneously resolved, but other blisters had formed. No home treatments were helpful; subject remained afebrile, without chills, anorexia, or spontaneous drainage, but it continues to be tender. Subject went to PCP (primary care provider) 5/6 afternoon, treated with diphenhydramine and amox-clav at 1600. Afterwards, subject had improved appetite (ate bread, rice, dinner), and fell asleep early at 1800, but missed a nap and had the diphenhydramine. Woke at 2000 in pain and was not consolable and not using his hand much, pulling his hand away when it was touched, so family presented to ED (emergency department). 16 m.o. male previously healthy and fully immunized presents with 1 days of streaking redness and swelling of his right hand without fever or infectious symptoms, likely due to cellulitis We need MR (Medical record) to further describe this collection and to help evaluate for a deep tissue infection (such as osteomyelitis, joint infection). This might be a rapidly progressive infection such as necrotizing soft tissue infection, but this was less likely given well-appearance without evidence of systemic toxicity, lack of high-risk injury such as traumatic wounds or immunosuppressed state, lack of out-of-proportion TTP (Thrombotic Thrombocytopenic Purpura) or skin necrosis/crepitus). Subject required admission for iv (intravenous) antibiotics and close monitoring, potentially requiring surgery.; Sender's Comments: A case of Cellulitis, 135 days after receiving the 1st dose of Varicella VNS vs Varivax, 1st dose of MMR vaccine,1st dose of Hepatitis A Vaccine and 1st dose of Prevnar 13, in a 16-month-old male subject. Report is inconsistent with causal relation to the vaccine product, considering implausible time to onset, absence of biological plausibility and alternative etiology (h/o unvaccinated dog bite/scratch)
Comments: On un-MAY-2026 MRI (Magnetic Resonance Imaging) hand right wow contrast Impression:1. Extensive dorsal cellulitis of the hand and wrist, with minimal superficial fascial fluid. No drainable abscess noted. 2. No evidence of osteomyelitis, nor septic joint. On un-MAy-2026 Ultrasound (U/S) shows a complex abscess with physical examination findings of fluctuance or induration.